The clinical importance of micrometastases within the lymphatic system in patients after total gastrectomy.

نویسندگان

  • Arkadiusz Spychała
  • Dawid Murawa
  • Konstanty Korski
چکیده

BACKGROUND In spite of radical gastrectomy with resection of the lymphatic system, where no metastases are found during histopathological examination, about 30% of patients have relapse of the neoplastic process. This situation may be caused by micrometastases or isolated neoplastic cells in the lymphatic system which were not identified during a standard histopathological examination. AIM The aim of the study was to evaluate the clinical importance of micrometastases within the lymphatic system in patients with gastric cancer. MATERIALS AND METHODS A group of 20 patients treated for gastric cancer were subjected to retrospective analysis. Of all the patients who underwent surgery, a group with tumours classified as T1 or T2 was selected. No metastases within the lymphatic system were found in the standard evaluation - N0 mark. Paraffin-embedded blocks of lymph nodes were cut and new specimens were made, which were then stained again by means of immunohistochemistry. Antibodies against cytokeratin AE1/AE3 were used. RESULTS A total of 319 lymph nodes were assessed in 20 patients in an H + E examination. After the immunohistochemical examination, micrometastases within the lymphatic system were found in 4 (20%) patients and isolated neoplastic cells in other 4 (20%) patients. CONCLUSION On the basis of numerous publications and our own material, we think that the presence of micrometastases may be related to a worse prognosis. The clinical importance of micrometastases within the lymphatic system in patients after total gastrectomy.

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عنوان ژورنال:
  • Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology

دوره 16 6  شماره 

صفحات  -

تاریخ انتشار 2011